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Catechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoids

✍ Scribed by Borchardt, Ronald T.; Huber, Joan A.


Book ID
126998649
Publisher
American Chemical Society
Year
1975
Tongue
English
Weight
367 KB
Volume
18
Category
Article
ISSN
0022-2623

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Inhibition of human erythrocyte and gast
✍ E. Schultz; S. Tarpila; A.-C. BΓ€ckstrΓΆm; A. Gordin; E. Nissinen; P. Pohto πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 367 KB

The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases