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Inhibition of catechol O-methyltransferase and transfer RNA methyltransferases by coralyne, nitidine, and related compounds

✍ Scribed by John W. Lee; John O. MacFarlane; Robert K. Y. Zee-Cheng; C. C. Cheng


Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
461 KB
Volume
66
Category
Article
ISSN
0022-3549

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Inhibition of human erythrocyte and gast
✍ E. Schultz; S. Tarpila; A.-C. BΓ€ckstrΓΆm; A. Gordin; E. Nissinen; P. Pohto πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 367 KB

The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases