Borate and molybdate inhibition of catechol estrogen and pyrocatechol methylation by catechol-O-methyltransferase
β Scribed by John H. Beattie; Els Weersink
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 794 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0162-0134
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The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases
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