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Inhibition of human liver catechol-O-methyltransferase by flavonoids

✍ Scribed by R. Gugler; H. J. Dengler


Book ID
112343691
Publisher
Springer-Verlag
Year
1973
Tongue
English
Weight
517 KB
Volume
276
Category
Article
ISSN
0028-1298

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Inhibition of human erythrocyte and gast
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The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases