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A semiempirical study on inhibition of catechol O-methyltransferase by substituted catechols

✍ Scribed by Martti Ovaska; Ari Yliniemelä

Book ID
110256840
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
251 KB
Volume
12
Category
Article
ISSN
0920-654X

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Inhibition of human erythrocyte and gast
Inhibition of human erythrocyte and gastroduodenal catechol-O-methyltransferase activity by nitecapone
✍ E. Schultz; S. Tarpila; A.-C. Bäckström; A. Gordin; E. Nissinen; P. Pohto 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 367 KB

The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases