Augmentation of the Pressor Response to Guanethedine by Inhibition of Catechol O-Methyltransferase
โ Scribed by WYLIE, D. W.
- Book ID
- 109614011
- Publisher
- Nature Publishing Group
- Year
- 1961
- Tongue
- English
- Weight
- 440 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/189490a0
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๐ SIMILAR VOLUMES
The effect of increasing single oral doses of the novel catechol-O-methyltransferase (COMT) inhibitor, nitecapone, on enzyme activity in red cells (RBC) and gastroduodenal COMT activity has been studied in healthy male volunteers. A dose-dependent decrease in RBC COMT activity was seen in all cases
## Abstract The short plasma halfโlife limits the antiparkinsonian efficacy of levodopa/carbidopa (LD/CD). Administration of LD/CD with the catecholโ__O__โmethyltransferase inhibitor entacapone in one tablet (LCE) may extend plasma halfโlife of LD and thus its effect on motor symptoms in patients w