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Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed and stimulate proteoglycan synthesis in healthy and osteoarthritic human articular chondrocytes

✍ Scribed by K Bobacz, A Soleiman, W Graninger, L Erlacher

Book ID: 120707822
Publisher: BioMed Central
Year: 2001
Tongue: English
Weight: 430 KB
Volume: 3
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar198

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## Abstract ## Objective Bone morphogenetic protein (BMP) and transforming growth factor β (TGFβ) are potent anabolic factors in adult articular chondrocytes. In this study, we investigated whether intracellular inhibitors of BMP and TGFβ signaling, inhibitory Smad6 (I‐Smad6) and I‐Smad7, are expr