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Statin stimulates bone morphogenetic protein-2, aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes

✍ Scribed by Hiroshi Hatano; Akihiro Maruo; Mark E. Bolander; Gobinda Sarkar

Publisher
Springer Japan
Year
2003
Tongue
English
Weight
270 KB
Volume
8
Category
Article
ISSN
0949-2658

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Objective. To study the effect of bone morphogenetic protein 2 (BMP-2) on articular cartilage proteoglycan (PG) synthesis in vivo and to investigate whether BMP-2 is able to counteract the effects of interleukin-1 (IL-1) on articular cartilage PG synthesis and content. Methods. BMP-2 alone or in co