## Abstract ## Objective To compare gene expression in normal and osteoarthritic (OA) human chondrocytes using microarray technology. Of the novel genes identified, we selected follistatin, a bone morphogenetic protein (BMP) antagonist, and investigated its expression/regulation as well as that of
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro
β Scribed by K. Bobacz; R. Gruber; A. Soleiman; L. Erlacher; J. S. Smolen; W. B. Graninger
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 294 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective Bone morphogenetic protein (BMP) and transforming growth factor Ξ² (TGFΞ²) are potent anabolic factors in adult articular chondrocytes. In this study, we investigated whether intracellular inhibitors of BMP and TGFΞ² signaling, inhibitory Smad6 (IβSmad6) and IβSmad7, are expr
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