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Caco-2 monolayers in experimental and theoretical predictions of drug transport

โœ Scribed by Per Artursson; Katrin Palm; Kristina Luthman


Book ID
114175900
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
833 KB
Volume
46
Category
Article
ISSN
0169-409X

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โœ Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 304 KB

Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2, cultured on permeable supports, are commonly used to predict the absorption of orally administered drugs and other xenobiotics. This protocol describes our method for the cultivation, characterization and dete