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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

✍ Scribed by Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per

Book ID
109946274
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
304 KB
Volume
2
Category
Article
ISSN
1750-2799

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Determination of drug permeability and p
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
✍ Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per πŸ“‚ Article πŸ“… 2007 πŸ› Nature Publishing Group 🌐 English βš– 304 KB

Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2, cultured on permeable supports, are commonly used to predict the absorption of orally administered drugs and other xenobiotics. This protocol describes our method for the cultivation, characterization and dete