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Analysis of Drug Permeation Across Caco-2 Monolayer: Implication for Predicting In Vivo Drug Absorption

โœ Scribed by Shinji Yamashita; Yoshihiro Tanaka; Yoriko Endoh; Yoko Taki; Toshiyasu Sakane; Tanekazu Nadai; Hitoshi Sezaki


Book ID
110309124
Publisher
Springer US
Year
1997
Tongue
English
Weight
489 KB
Volume
14
Category
Article
ISSN
0724-8741

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โœ Hubatsch, Ina; Ragnarsson, Eva G E; Artursson, Per ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 304 KB

Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2, cultured on permeable supports, are commonly used to predict the absorption of orally administered drugs and other xenobiotics. This protocol describes our method for the cultivation, characterization and dete