𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Determination of the stereoselectivity of chiral drug transport across Caco-2 cell monolayers

✍ Scribed by Ying He; Su Zeng


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
256 KB
Volume
18
Category
Article
ISSN
0899-0042

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Stereoselective transport and uptake of
✍ Yi Wang; Jiang Cao; Xiaodan Wang; Su Zeng 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views

## Abstract The transport and uptake of individual propranolol (PPL) enantiomers were studied in human intestinal Caco‐2 cell monolayers, and a reversed‐phase HPLC‐UV assay was used for quantitative analysis. S‐PPL and R‐PPL across Caco‐2 cell monolayers was determined in the concentrations range o

P-glycoprotein–mediated transport of ber
✍ Han-Joo Maeng; Ho-Jung Yoo; In-Wha Kim; Im-Sook Song; Suk-Jae Chung; Chang-Koo S 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB

The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras

Transport of cosalane—a highly lipophili
✍ Dhananjay Pal; Chandrasekhar Udata; Ashim K. Mitra 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB 👁 1 views

Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral bioavailability of this highly lipophilic compound is extremely poor (<1%). Also, cosalane accumulates in high concentration in the liver after intravenous administration, with c

Effect of cationized gelatins on the par
✍ Toshinobu Seki; Hiroshi Kanbayashi; Tomonobu Nagao; Sumio Chono; Yasuhiko Tabata 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB

Cationized gelatins, candidate absorption enhancers, were prepared by addition of ethylenediamine or spermine to gelatin and the effects of the resulting ethylenediaminated gelatin (EG) and sperminated gelatin (SG) on the paracellular transport of 5(6)-carboxyfluorescein (CF), FITC-dextran-4 (FD4),