𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bridging the Gap: Human Diploid Cell Strains and the Origin of AIDS

✍ Scribed by BILLI GOLDBERG; RAPHAEL B STRICKER

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
138 KB
Volume
204
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

✦ Synopsis

Recent descriptions of the "rst human and chimpanzee cases of human immunode"ciency virus type 1 (HIV-1)-related retroviral infections dating from 1959 have stirred interest in the origin of AIDS. Although the theory of a chimpanzee origin of HIV-1 with cross-species transfer to man has now gained popularity, a more likely scenario is that chimps and humans were infected by an HIV-1 precursor virus derived from a contaminated poliovaccine. The reason for the rapidity and ease of cross-species transfer of this precursor virus has not been elucidated. We hypothesize that the poliovaccine was passaged in a human diploid cell strain. This simple manipulation allowed the retrovirus to adapt to human tissues and may have spawned the AIDS pandemic.

πŸ“œ SIMILAR VOLUMES

Respiration and glycolysis in the human
Respiration and glycolysis in the human diploid cell strain wi-38
✍ V. J. Cristofalo; David Kritchevsky πŸ“‚ Article πŸ“… 1966 πŸ› John Wiley and Sons 🌐 English βš– 610 KB

Assessment of the respiratory and glycolytic capacity of non-growing WI-38 cells shows that, in the absence and presence of added glucose, the mean rates of oxygen consumption were 247 (QOz = 5.61) and 208 (QOz = 4.73) mpmoles/mg dry wt/hr., respectively. Mean glucose consumption was 225 mpmoles/mg

The influence of progressive growth on t
The influence of progressive growth on the specific catalase activity of human diploid cell strains. I. Effect of cellular genotype: Homozygous strains
✍ Yue-Liang Pan; Robert S. Krooth πŸ“‚ Article πŸ“… 1968 πŸ› John Wiley and Sons 🌐 English βš– 621 KB

The specific catalase activity of human diploid cell strains increases with progressive growth of the culture, and falls again following subculture. Although the increase is small, it is readily demonstrable, and is exponential with time. The response of catalase activity to progressive growth of t

Porcine induced pluripotent stem cells m
Porcine induced pluripotent stem cells may bridge the gap between mouse and human iPS
✍ Miguel A. Esteban; Meixiu Peng; Zhang Deli; Jie Cai; Jiayin Yang; Jianyong Xu; L πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 221 KB

## Abstract Recently, three independent laboratories reported the generation of induced pluripotent stem cells (iPSCs) from pig (__Sus scrofa__). This finding sums to the growing list of species (mouse, human, monkey, and rat, in this order) for which successful reprogramming using exogenous factor

The influence of progressive growth on t
The influence of progressive growth on the specific catalase activity of human diploid cell strains. II. Effect of cellular genotype: A heterozygous strain
✍ Yue-Liang Pan; Robert S. Krooth; Shigeo Takahara πŸ“‚ Article πŸ“… 1968 πŸ› John Wiley and Sons 🌐 English βš– 181 KB

Human diploid cell strains develop progressively higher levels of specific catalase activity as they grow. Following subculture activity falls again. A diploid cell strain heterozygous for the gene for acatalasia I (acatalasemia) was found to develop specific catalase activity at proportionately the

Characterization of the cell cycle of cu
Characterization of the cell cycle of cultured human diploid cells: Effects of aging and hydrocortisone
✍ Gary L. Grove; Vincent J. Cristofalo πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 599 KB

## Abstract Age‐related changes in the cytokinetics of human diploid cells __in vitro__ have been compared in normal cultures and in cultures in which lifespan has been prolonged by the addition of hydrocortisone to the medium. For both cultures, with advancing age the fraction of cells in the acti