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The influence of progressive growth on the specific catalase activity of human diploid cell strains. II. Effect of cellular genotype: A heterozygous strain

✍ Scribed by Yue-Liang Pan; Robert S. Krooth; Shigeo Takahara

Publisher: John Wiley and Sons
Year: 1968
Tongue: English
Weight: 181 KB
Volume: 71
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040710206

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✦ Synopsis

Human diploid cell strains develop progressively higher levels of specific catalase activity as they grow. Following subculture activity falls again. A diploid cell strain heterozygous for the gene for acatalasia I (acatalasemia) was found to develop specific catalase activity at proportionately the same rate as normal cell strains. Yet the mutant gene reduced the absolute level of specilk catalase activity which the culture attained at any given point in time. In this respect the heterozygous acatalasia I strain resembles the homozygous acatalasia I1 strain previously reported.

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The influence of progressive growth on t

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✍ Yue-Liang Pan; Robert S. Krooth 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 621 KB

The specific catalase activity of human diploid cell strains increases with progressive growth of the culture, and falls again following subculture. Although the increase is small, it is readily demonstrable, and is exponential with time. The response of catalase activity to progressive growth of t

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✍ Yue-Liang Pan; Robert S. Krooth 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

It was shown previously that the specific catalase activity of human diploid cell strains falls immediately after subculture and then progressively rises in an exponential fashion. In this paper evidence is presented suggesting that the rise in catalase activity cannot be due to an accumulation with