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The influence of progressive growth on the specific catalase activity of human diploid cell strains. III. Experiments bearing on the mechanism responsible for change in specific activity

✍ Scribed by Yue-Liang Pan; Robert S. Krooth

Publisher: John Wiley and Sons
Year: 1968
Tongue: English
Weight: 676 KB
Volume: 71
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040710207

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✦ Synopsis

It was shown previously that the specific catalase activity of human diploid cell strains falls immediately after subculture and then progressively rises in an exponential fashion. In this paper evidence is presented suggesting that the rise in catalase activity cannot be due to an accumulation within the cell of a small molecule which enhances enzyme activity in cell-free extracts. It is also shown that activity per cell, as well as per unit cell protein, rises as the culture grows.

The rate of fall of specific catalase activity immediately after subculture is greater if the cells are at a low population density than if they are at a high one. The rate

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Human diploid cell strains develop progressively higher levels of specific catalase activity as they grow. Following subculture activity falls again. A diploid cell strain heterozygous for the gene for acatalasia I (acatalasemia) was found to develop specific catalase activity at proportionately the