## Abstract Rapid equilibrium of Dโ and Lโphenylalanines with phenylpyruvic acid (**4**) was shown to account for their equally efficient incorporation into cytochalasin D (**1**) by __Zygosporium masonii__. Transamination of phenylalanines stereospecifically labelled with tritium at C(2) and C(3)
Biosynthesis of cytochalasans. Part 5. The Incorporation of Deoxaphomin into Cytochalasin B (Phomin)
โ Scribed by Jean-Louis Robert; Christoph Tamm
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- German
- Weight
- 468 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0018-019X
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โฆ Synopsis
Abstract
Radioactive deoxaphomin (1) which was obtained by feeding [4โฒโ^3^H, Uโ^14^C]โLโphenylalanine to cultures of Phoma sp. (S298) was shown to be well incorporated into cytochalasin B (phomin) (2). The results demonstrate that 1 is an immediate biogenetic precursor of 2.
๐ SIMILAR VOLUMES
## Abstract Sequential single frequency decoupling and partially relaxed __Fourier__ transform (PRFT) are used to assign the natural abundance ^13^CโNMR. spectra of cytochalasin B (phomin) (**1**) and cytochalasin D (**2**). Cultures of __Phoma spec.__ S 298 were fed [2โ^13^C]โsodium acetate, and t
The synthesis of methyl (4R, 8RJ-lO-bromo-8-methyl-4-( 1,3,6-trioxaheptane)-2-deceneoate (3, a synthon for the construction of the macrocyclic moieties of the cytochalasins A (l), B (2), F (3) and desoxaphomin (4) is described. (S)-Glutamic acid (6) was transformed to the C,-epoxide 10 and 3-methylg
The biosynthesis of the tetrahydroanthraquinone, altersolanol A (I), by Alternaria solani has been established by the incorporation of [1,2-13C2]-acetate. A blocked culture of A. sm was utilized to reveal that 1 is metabolized to altersolanol B and macrosporin. --Altersolanol A (1) and B (Z), member
Timecourse studies were performed which compared the influence of 5-methyltryptophan to tryptophan on alkaloid formation in ergot strain SD-58. Evidence was obtained that confirms the role of tryptophan as an inducer of alkaloid synthesis. Additional studies were conducted to determine the incorpora
## Abstract Incorporation of (3R)โ[(5R)โ5โ^3^H]โmevalonate into verrucarin followed by hydrolyses to verrucarol (2) and transformation of the latter to the spirolactol 5 and the spirolactone 6 successively, demonstrate the identity of the C(11)โhydrogen of the trichothecane skeleton with the 5โโpro