Metabolites of Alternaria solani part V. Biosynthesis of altersolanol A and incorporation of altersolanol A-13Cx into altersolanol B and macrosporin

✍ Scribed by Albert Stoessl; C.H. Unwin; J.B. Stothers

• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 197 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)86326-7

✦ Synopsis

The biosynthesis of the tetrahydroanthraquinone, altersolanol A (I), by Alternaria solani has been established by the incorporation of [1,2-13C2]-acetate. A blocked culture of A. sm was utilized to reveal that 1 is metabolized to altersolanol B and macrosporin. --Altersolanol A (1) and B (Z), members of a very small group of naturally occurring tetrahydroanthraquinones, are of interest as antibiotics5 and as metabolites of the important plant-pathogenic fungi, Alternaria solani l-4 and A. porri. 6 These compounds have also been isolated from Phomopsis juniperivora7 and Dactylaria u, 5 while 2 has recently been synthesized' as a simpler analog of the anthracyclinones. We now report that 1 is metabolized by