Biodistribution of Neocarzinostatin Conjugated to Chimeric Fab Fragments of the Monoclonal Antibody A7 in Nude Mice Bearing Human Pancreatic Cancer Xenografts
โ Scribed by Otsuji, Eigo ;Yamaguchi, Toshiharu ;Yamaoka, Nobuki ;Taniguchi, Katsunori ;Kato, Makoto ;Kotani, Tatsuya ;Kitamura, Kazuya ;Takahashi, Toshio
- Book ID
- 108580838
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1994
- Tongue
- English
- Weight
- 334 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0910-5050
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The anticancer agent neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of the monoclonal antibody A7 to form the conjugate chA7Fab-NCS. The antitumor effect of chA7Fab-NCS was tested by measuring the inhibition of 3H-thymidine incorporation into human pancreatic carci
Xenografts of a human pancreatic carcinoma cell line, HPC-YS, which reacted with the monoclonal antibody (MAb) A7, were used to investigate the in vivo localization of radioiodinated MAb A7 after intraperitoneal injection. MAb A7 localized to the tumor 4 days and 8 days after injection with a tissue
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