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Biocompatibility testing of polymers:In vivo implantation studies

✍ Scribed by Gourlay, Stuart J. ;Rice, Robert M. ;Hegyeli, Andrew F. ;Wade, Clarence W. R. ;Dillon, James G. ;Jaffe, Howard ;Kulkarni, R. K.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
612 KB
Volume
12
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

An in vivo method is described for screening polymeric materials for biocompatibility. The test is based on grading acute and subacute tissue reactions at 7 and 28 days, respectively, following implantation in rats. The method is reproducible and reliable. It is designed to provide uniform test criteria for biocompatibility assessment in the early phases of the development of surgical implant materials.

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