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Biocompatibility testing of polymers:In vitro studies within vivo correlation

โœ Scribed by Rice, Robert M. ;Hegyeli, Andrew F. ;Gourlay, Stuart J. ;Wade, Clarence W. R. ;Dillon, James G. ;Jaffe, Howard ;Kulkarni, R. K.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
557 KB
Volume
12
Category
Article
ISSN
0021-9304

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โœฆ Synopsis

An zn vztro method has been developed for screening of candidate biomaterials in an early phase of their development. The test is based on L-929 mouse fibroblast cultures and their response to powdered polymer samples. I t applies microscopic observation for the detection of morphological changes, uses dye exclusion testing for cell viability determination, and utilizes estimation of population doublings as an end point. The test is shown to be reliable and reproducible and is compared to zn WJO implantation studies in rats, previously reported.

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