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Re: Biocompatibility testing of polymers:In vitro studies within vivo correlation

✍ Scribed by Leininger, R. I.

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
55 KB
Volume
12
Category
Article
ISSN
0021-9304

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✦ Synopsis

In the recent paper by R. M. Rice, et a1.l I am quoted as having said "that no compound which is nontoxic in uitro will be toxic by intramuscular implantation."2 The impression created is that this was a general conclusion reached by me in this review paper. In actuality, although a very similar statement occurs in my paper, it was not given as a conclusion. Rather, it was a portion of my summary of the results of work by Rosenbl~th.~ Apart from the aforementioned, the use of powdered materials for in uitro evaluations is certainly another step in the study of biocompatibility. Powdered materials were used as a means of magnifying in uiuo effects about thirty years ago on the basis of increasing the area of material-tissue contact. Increased surface area could act through increases in (1) the rate of leaching of nonpolymeric components, (2) the rate of degradation, or (3) the opportunity for physico-chemical effects. Size, shape, and surface areas of the powders would have to be closely controlled if valid ranking of the polymers were desired. As to the differences found in the in uitro evaluations reported in this paper and the in uiuo tests reported elsewhere, it is suggested that the duration of the tests may be a factor. The in uitro tests were 48 hr, which is much shorter than the usual in uiuo tests. Thus, is it possible that slowly extractible irritants would show a greater effect in the longer in viuo tests?

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