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In Vivo Biocompatibility of Three Potential Intraperitoneal Implants

✍ Scribed by Sylvie Defrère; Mélanie Mestagdt; Raphaël Riva; Fabrice Krier; Anne Van Langendonckt; Pierre Drion; Christine Jérôme; Brigitte Evrard; Jean-Paul Dehoux; Jean-Michel Foidart; Jacques Donnez

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
554 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

The intraperitoneal biocompatibility of PDMS, polyHEMA and pEVA was investigated in rats, rabbits and rhesus monkeys. No inflammation was evidenced by hematological analyses and measurement of inflammatory markers throughout the experiment and by post‐mortem examination of the pelvic cavity. After 3 or 6 months, histological analysis revealed fibrous tissue encapsulating PDMS and PEVA implants in all species and polyHEMA implants in rabbits and monkeys. Calcium deposits were observed inside polyHEMA implants. The intraperitoneal biocompatibility of all 3 polymers makes them suitable for the design of drug delivery systems, which may be of great interest for pathologies confined to the pelvic cavity.

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