BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist
✍ Scribed by Yvan Dumont; Alain Cadieux; Henri Doods; Leng Hong Pheng; Roger Abounader; Edith Hamel; Danielle Jacques; Domenico Regoli; Rémi Quirion
- Book ID
- 110004865
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 839 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0007-1188
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📜 SIMILAR VOLUMES
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.
Recently, we reported the bioisosteric substitution of a guanidine by an acylguanidine entity in argininamide-type neuropeptide Y (NPY) Y 1 receptor (Y 1 R) antagonists, such as BIBP 3226 [1] (1; Scheme 1), to be an effective strategy for the [a] Dr.
## Abstract For Abstract see ChemInform Abstract in Full Text.