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Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y2 receptor antagonist, in vivo

✍ Scribed by Rickard E Malmström

Book ID
110005789
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
207 KB
Volume
133
Category
Article
ISSN
0007-1188

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The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.