The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists

✍ Scribed by Gillian E. Lunniss; Ashley A. Barnes; Nick Barton; Matteo Biagetti; Federica Bianchi; Stephen M. Blowers; Laura L. Caberlotto; Amanda Emmons; Ian P. Holmes; Dino Montanari; Roz Norris; Gemma V. Puckey; Dewi J. Walters; Steve P. Watson; John Willis

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 678 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.10.065

✦ Synopsis

The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.