✦ LIBER ✦

Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis

✍ Scribed by Debaene, François; Winssinger, Nicolas

Book ID: 118063133
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 92 KB
Volume: 5
Category: Article
ISSN: 1523-7060
DOI: 10.1021/ol0358408

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of peptide nucleic acids (PNA)

Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis

✍ Lutz S. Richter; Ronald N. Zuckermann 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 250 KB

Solid-Phase synthesis of peptide nucleic

Solid-Phase synthesis of peptide nucleic acids

✍ Dr. Leif Christensen; Richard Fitzpatrick; Brian Gildea; Kenneth H. Petersen; He 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA

Solid phase synthesis of protected pepti

Solid phase synthesis of protected peptide nucleic acids

✍ Oliver Seitz 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 234 KB

Boc/'Z-protected PNA oligomers were synthesised on solid phase. The use of the allylic HYCRON resin allowed for the application of both Boc-and Fmoc-protecting groups. Highest yields were obtained when the monomeric building block was synthesised on solid phase rather than loaded as preformed unit.

Solid-phase synthesis of pseudo-compleme

Solid-phase synthesis of pseudo-complementary peptide nucleic acids

✍ Komiyama, Makoto; Aiba, Yuichiro; Ishizuka, Takumi; Sumaoka, Jun 📂 Article 📅 2008 🏛 Nature Publishing Group 🌐 English ⚖ 261 KB

Solid-Phase Synthesis of Peptide-Derived

Solid-Phase Synthesis of Peptide-Derived Enantiospecific Nucleic Acid Analogs

✍ Vibhakar J. Shah; Robert Cerpa; Irwin D. Kuntz; Jr.; George L. Kenyon 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 207 KB

The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N 9 -adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (

Solid-phase synthesis of peptide nucleic

Solid-phase synthesis of peptide nucleic acid (PNA) monomers and their oligomerization using disulphide anchoring linkers

✍ Gudrun Aldrian-Herrada; Alain Rabié; Reinhold Wintersteiger; Jean Brugidou 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

A new simple solid-phase method has been developed for synthesizing Boc-protected peptide nucleic acid (PNA) monomers. An immobilized backbone 3 was built on Expansin ® resin using an ester disulphide handle: 2-hydroxypropyl-dithio-2%-isobutyric acid (HPDI). The base acetic acids of thymine 5, Z-cyt