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Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases

✍ Scribed by Furneaux, Richard H.; Greatrex, Ben; Murkin, Andrew S.; Schramm, Vern L.; Tyler, Peter C.; Evans, Gary B.

Book ID: 111677834
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 175 KB
Volume: 51
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm701265n

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A number of 1,4--didcoxy-l,4-imino-l-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been s3aithesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected

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