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Syntheses and bio-activities of the l-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases

โœ Scribed by Clinch, Keith; Evans, Gary B.; Fleet, George W. J.; Furneaux, Richard H.; Johnson, Stephen W.; Lenz, Dirk H.; Mee, Simon P. H.; Rands, Peter R.; Schramm, Vern L.; Taylor Ringia, Erika A.; Tyler, Peter C.


Book ID
119948009
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
204 KB
Volume
4
Category
Article
ISSN
1477-0520

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Synthesis of Transition State Analogue I
โœ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 314 KB

AbstractรSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxyยฏuoro-and 2-deoxy-analogues and others having modiยฎed bases.