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Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases

โœ Scribed by Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter C. Tyler

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
314 KB
Volume
56
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

AbstractรSyntheses of the `Immucillins', potent aza-C-nucleoside inhibitors of purine nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deoxyยฏuoro-and 2-deoxy-analogues and others having modiยฎed bases.

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ChemInform Abstract: Synthesis of Transi
ChemInform Abstract: Synthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases.
โœ Gary B. Evans; Richard H. Furneaux; Graeme J. Gainsford; Vern L. Schramm; Peter ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โ€œFull Textโ€ option. The original article is trackable v

Synthesis of transition state inhibitors
Synthesis of transition state inhibitors for N-riboside hydrolases and transferases
โœ Richard H Furneaux; Gerrit Limberg; Peter C Tyler; Vern L Schramm ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 752 KB

A number of 1,4--didcoxy-l,4-imino-l-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been s3aithesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected