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Synthesis of transition state inhibitors for N-riboside hydrolases and transferases

โœ Scribed by Richard H Furneaux; Gerrit Limberg; Peter C Tyler; Vern L Schramm

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
752 KB
Volume
53
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

A number of 1,4--didcoxy-l,4-imino-l-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been s3aithesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.

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