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The Synthesis of N-Ribosyl Transferase Inhibitors Based on a Transition State Blueprint.

✍ Scribed by Gary B. Evans


Publisher
John Wiley and Sons
Year
2004
Weight
7 KB
Volume
35
Category
Article
ISSN
0931-7597

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Efficient Sialyltransferase Inhibitors B
✍ Bernd MΓΌller; Christoph Schaub; Richard R. Schmidt πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 161 KB πŸ‘ 2 views

A 200- to 1000-fold higher affinity for sialyltransferase is shown by compounds 1 and 2 relative to the natural substrate. These inhibitors, which are derived from the transition state of S 1-type sialyltransfer, contain a flat ring that is attached through a carbon atom with a phosphonate and a cyt