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KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic

โœ Scribed by Yoshiaki Kiso; Satoshi Yamaguchi; Hikaru Matsumoto; Tsutomu Mimoto; Ryohei Kato; Satoshi Nojima; Haruo Takaku; Tominaga Fukazawa; Tooru Kimura; Kenichi Akaji


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
44 KB
Volume
331
Category
Article
ISSN
0365-6233

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: KNI-577, a Potent S
โœ Y. KISO; S. YAMAGUCHI; H. MATSUMOTO; T. MIMOTO; R. KATO; S. NOJIMA; H. TAKAKU; T ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB

KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic -[synthesis of the title compound (I), which exhibits potent antiviral activities, low cytotoxicity and good pharmacokinetic properties after i

Small dipeptide-based HIV protease inhib
โœ Yoshiaki Kiso; Hikaru Matsumoto; Sota Mizumoto; Tooru Kimura; Yoichi Fujiwara; K ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 312 KB

The human immunodeficiency virus (HIV) codes for an aspartic protease known to be essential for retroviral maturation and replication. HIV protease is formed from two identical 99 amino acid peptides. We synthesized [(NHCH 2 CH 2 -S-CH 2 CO) [51][52] , Ala 67,95 ]HIV-1 protease using the thioether c