KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic -[synthesis of the title compound (I), which exhibits potent antiviral activities, low cytotoxicity and good pharmacokinetic properties after i
โฆ LIBER โฆ
KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic
โ Scribed by Yoshiaki Kiso; Satoshi Yamaguchi; Hikaru Matsumoto; Tsutomu Mimoto; Ryohei Kato; Satoshi Nojima; Haruo Takaku; Tominaga Fukazawa; Tooru Kimura; Kenichi Akaji
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 44 KB
- Volume
- 331
- Category
- Article
- ISSN
- 0365-6233
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๐ SIMILAR VOLUMES
ChemInform Abstract: KNI-577, a Potent S
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Y. KISO; S. YAMAGUCHI; H. MATSUMOTO; T. MIMOTO; R. KATO; S. NOJIMA; H. TAKAKU; T
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2010
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John Wiley and Sons
โ 29 KB
Small dipeptide-based HIV protease inhib
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Yoshiaki Kiso; Hikaru Matsumoto; Sota Mizumoto; Tooru Kimura; Yoichi Fujiwara; K
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Article
๐
1999
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Wiley (John Wiley & Sons)
๐
English
โ 312 KB
The human immunodeficiency virus (HIV) codes for an aspartic protease known to be essential for retroviral maturation and replication. HIV protease is formed from two identical 99 amino acid peptides. We synthesized [(NHCH 2 CH 2 -S-CH 2 CO) [51][52] , Ala 67,95 ]HIV-1 protease using the thioether c