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ChemInform Abstract: KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic

✍ Scribed by Y. KISO; S. YAMAGUCHI; H. MATSUMOTO; T. MIMOTO; R. KATO; S. NOJIMA; H. TAKAKU; T. FUKAZAWA; T. KIMURA; K. AKAJI

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199825242

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✦ Synopsis

KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic -[synthesis of the title compound (I), which exhibits potent antiviral activities, low cytotoxicity and good pharmacokinetic properties after intraduodenal administration]. -(KISO, Y.;

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