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Efficient Sialyltransferase Inhibitors Based on Transition-State Analogues of the Sialyl Donor

✍ Scribed by Bernd Müller; Christoph Schaub; Richard R. Schmidt

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
161 KB
Volume
37
Category
Article
ISSN
0044-8249

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✦ Synopsis

A 200- to 1000-fold higher affinity for sialyltransferase is shown by compounds 1 and 2 relative to the natural substrate. These inhibitors, which are derived from the transition state of S 1-type sialyltransfer, contain a flat ring that is attached through a carbon atom with a phosphonate and a cytidine monophosphate group.

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