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Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

✍ Scribed by Georgios M. Hadjigeorgiou; Georgia Xiromerisiou; Vanessa Gourbali; Kostantinos Aggelakis; Nikolaos Scarmeas; Alexandros Papadimitriou; Andrew Singleton

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
74 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The α‐synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80–5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58–3.10). Kaplan–Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD. © 2005 Movement Disorder Society

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