A strong association has been described in cross-sectional studies between the ~4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the ~4 allele in 6 2 sporadic LOAD (onset at age 70 and over) patients. Di
Apolipoprotein E4 allele and Alzheimer disease: Examination of Allelic association and effect on age at onset in both early-and late-onset cases
β Scribed by P. A. Locke; P. M. Conneally; R. E. Tanzi; J. F. Gusella; J. L. Haines
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 671 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0741-0395
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β¦ Synopsis
An increased frequency of the apolipoprotein E type 4 allele (APOE-4) has previously been associated with both late-onset sporadic and late-onset familial Alzheimer disease (AD) [
π SIMILAR VOLUMES
It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b
## Abstract ## Objective This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoproteinβE epsilon 4 allele (__APOE__ Ξ΅4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic g