## Abstract Different lines of evidence indicate that methylenetetrahydrofolate reductase (__MTHFR__) functional gene polymorphisms, causative in aberrant folate–homocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Opposing views are exp
Association between the TNFα-308 A/G polymorphism and the onset-age of Alzheimer disease
✍ Scribed by Alvarez, Victoria ;Mata, Ignacio F. ;González, Pelayo ;Lahoz, Carlos H. ;Martínez, Carmen ;Peña, Joaquín ;Guisasola, Luis M. ;Coto, Eliecer
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 59 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0148-7299
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Tumor necrosis factor (TNF), a proinflammatory cytokine, may be involved in the pathogenesis of Alzheimer disease (AD) based on observations that senile plaques have been found to upregulate proinflammatory cytokines. Additionally, nonsteroidal anti-inflammatory drugs have been found to delay and pr
## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.