Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess
No association between the NOS3 codon 298 polymorphism and Alzheimer's disease in a sample from the United States
โ Scribed by Fiona Crawford; Melissa Freeman; Laila Abdullah; John Schinka; Mike Gold; Ranjan Duara; Mike Mullan
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 184 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc
It is now commonly known that possession of one of the three common alleles of the apolipoprotein E (APOE) gene (allele epsilon 4) confers an increased risk for both familial and sporadic Alzheimer's disease (AD), and that this risk is dose-dependent. Other genes that may play a role in AD, either t