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Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

✍ Scribed by Masataka Nishimura; Sadako Kuno; Ikuko Mizuta; Mitsuhiro Ohta; Hirofumi Maruyama; Ryuji Kaji; Hideshi Kawakami

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
264 KB
Volume
18
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society

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