Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer
✍ Scribed by Anna Sivula; Anne Talvensaari-Mattila; Johan Lundin; Heikki Joensuu; Caj Haglund; Ari Ristimäki; Taina Turpeenniemi-Hujanen
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 273 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0167-6806
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## Abstract ## Introduction The cyclooxygenase‐2 (COX‐2), responsible for the conversion of arachidonic acid into prostaglandin (PG) E2, is known to increase intracellular cAMP and estrogen production in malignant breast tissue. The aromatase enzyme complex is responsible for local production of e
## Background: Matrix metalloproteinase-2 (mmp-2), which degrades the extracellular matrix or the basement membrane, has an essential role in tumor invasion and metastasis. to evaluate the roles of mmp-2, its inhibitor (tissue inhibitor of metalloproteinase-2 [timp-2]), and its activator (membrane-