𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer

✍ Scribed by M. Salhab; G. Singh-Ranger; R. Mokbel; F. Jouhra; W.G. Jiang; K. Mokbel

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
96 KB
Volume
96
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Introduction

The cyclooxygenase‐2 (COX‐2), responsible for the conversion of arachidonic acid into prostaglandin (PG) E2, is known to increase intracellular cAMP and estrogen production in malignant breast tissue. The aromatase enzyme complex is responsible for local production of estrogens in breast cancer. Increasing evidence supports a role for COX‐2 in upregulation of aromatase activity. The aim of this study was to examine the relationship between COX‐2 and aromatase mRNA expression in human breast cancer.

Methods

A total of 160 breast samples (127 tumor tissues and 33 normal tissues) were analyzed. Levels of transcription were determined using real‐time quantitative PCR. COX‐2 and aromatase mRNA expression were normalized against CK19. Levels of expression of COX‐2 were correlated with those of aromatase using Pearson's correlation method.

Results

Levels of expression of COX‐2/CK19 of both benign and malignant tissues were positively correlated with aromatase/CK19 transcript levels (correlation coefficient = +0.536, P < 0.0001). When we compared levels of expression of both genes in malignant samples only, there was a highly significant positive correlation (r = +0.611, P < 0.00001).

Conclusion

This study demonstrates a strong positive relationship between COX‐2 and aromatase mRNA expression, and lends further support to the hypothesis that COX‐2 is an upregulator of aromatase in breast tissue. J. Surg. Oncol. 2007;96:424–428. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

htert expression correlates with MYC ove
htert expression correlates with MYC over-expression in human prostate cancer
✍ Alain Latil; Dominique Vidaud; Antoine Valéri; Georges Fournier; Michel Vidaud; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 63 KB 👁 2 views

Expression of the telomerase catalytic sub-unit (htert) constitutes a key step in the development of human cancer. Although htert regulation is still unclear, several studies suggest that c-myc may activate its expression. Prostate cancer is one of the most common malignancies among men in Western c

Expression of ADAM-9 mRNA and protein in
Expression of ADAM-9 mRNA and protein in human breast cancer
✍ Caroline O'Shea; Norman McKie; Yvonne Buggy; Catherine Duggan; Arnold D.K Hill; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 410 KB 👁 2 views

## Abstract The ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance of ADAM

Correlation of p27 protein expression wi
Correlation of p27 protein expression with HER-2/neu expression in breast cancer
✍ Lisa Newman; Weiya Xia; Heng-Yin Yang; Aysegal Sahin; Melissa Bondy; Farzana Luk 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB

## Abstract Strong expression of human epidermal growth factor receptor 2 (HER‐2)/neu in breast cancer has been associated with poor prognosis. Reduced expression of p27^Kip1^, a cyclin‐dependent kinase inhibitor, correlates with poor clinical outcome in breast cancer. In this study, we provide a c

Expression and prognostic value of lacto
Expression and prognostic value of lactoferrin mRNA isoforms in human breast cancer
✍ Monique Benaïssa; Jean-Philippe Peyrat; Louis Hornez; Christophe Mariller; Joël 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB 👁 2 views

## Abstract We investigated the expression levels of human lactoferrin (Lf), a steroid hormone‐inducible gene product the expression of which is often altered during oncogenesis, and of Δ‐lactoferrin (ΔLf), its alternative isoform, which has been shown to be absent from tumor cell lines in commonly

Mutation analysis and mRNA expression of
Mutation analysis and mRNA expression of trail-receptors in human breast cancer
✍ Susanne Seitz; Peter Wassmuth; Jörg Fischer; Anita Nothnagel; Burkhard Jandrig; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 316 KB 👁 2 views

## Abstract The chromosome region 8p12‐p22 shows frequent allelic loss in a variety of human malignancies, including breast cancer (BC). The tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL)‐receptors TRAIL‐R1, ‐R2, ‐R3 and ‐R4 are located on 8p21‐p22 and might be candidate tumor supp