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Correlation of p27 protein expression with HER-2/neu expression in breast cancer

✍ Scribed by Lisa Newman; Weiya Xia; Heng-Yin Yang; Aysegal Sahin; Melissa Bondy; Farzana Lukmanji; Mien-Chie Hung; Mong-Hong Lee

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
156 KB
Volume
30
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

Strong expression of human epidermal growth factor receptor 2 (HER‐2)/neu in breast cancer has been associated with poor prognosis. Reduced expression of p27^Kip1^, a cyclin‐dependent kinase inhibitor, correlates with poor clinical outcome in breast cancer. In this study, we provide a correlation between these two important prognostic markers in patients with breast cancer. Breast tumor screening using immunohistochemistry indicated that downregulation of p27 correlated with HER‐2/neu overexpression in studying 11 normal breast tissues and 51 primary breast carcinomas. We found HER‐2/neu protein overexpression in 20 (41%) of 49 breast cancers and low p27 protein expression in 47 (92%) of 51 breast cancers. All 20 (100%) of the tumors that overexpressed HER‐2/neu had low levels of p27 protein product; this correlation was statistically significant (P = 0.035). Decreasing p27 expression correlated with increasing HER‐2/neu activity. Our results suggest that one function of the HER‐2/neu product is to downregulate p27 expression in breast cancer. This study may be significant in selecting patients for HER‐2/neu antibody therapy in the future. Mol. Carcinog. 30:169–175, 2001. Β© 2001 Wiley‐Liss, Inc.

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