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Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro

โœ Scribed by Flavia Zanzoni; E. G. Jung

Publisher
Springer-Verlag
Year
1980
Tongue
English
Weight
250 KB
Volume
267
Category
Article
ISSN
0340-3696

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โœฆ Synopsis

The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2 x 10-6M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.

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## Abstract The utility of the sister chromatid exchange (SCE) assay for human population studies is potentially limited by the variability associated with individual baseline SCE frequencies. This investigation identifies and quantifies the major sources of preparative and biological variation ass