๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic

โœ Scribed by Walter Burgdorf; Karen Kurvink; Jaroslav Cervenka

Publisher
Springer
Year
1977
Tongue
English
Weight
224 KB
Volume
36
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

โœฆ Synopsis

An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/ mitosis. Chromosome breakage analysis revealed no difference between the two groups.

SCE rate has been shown to be elevated in a variety of systems where cell cultures or experimental animals were exposed to known mutagens and carcinogens. We suggest that the relationship carcinogen exposure-elevated SCE rate-cancer may also be valid in humans treated with arsenic.

๐Ÿ“œ SIMILAR VOLUMES

Arsenic elevates the sister chromatid ex
Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro
โœ Flavia Zanzoni; E. G. Jung ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 250 KB

The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2 x 10-6M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitiv

Sister chromatid exchange distributions
Sister chromatid exchange distributions in rabbit lymphocytes treated with streptonigrin
โœ DuFrain, Russell J. ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Wiley (John Wiley & Sons) โš– 611 KB

Streptonigrin (NSC-45383), a direct-acting clastogen which induces SCEs in vivo and chromosome aberrations both in vivo and in vitro, was evaluated for SCE induction in both Go and stimulated rabbit lymphocytes. Determinations were made for 16 cultures from seven female rabbits. These included contr

Sister chromatid exchange in peripheral
Sister chromatid exchange in peripheral lymphocytes of subjects vaccinated against measles
โœ B. Lambert; A. Ehrnst; K. Hansson; A. Lindblad; M. Morad; B. Werelius ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Springer ๐ŸŒ English โš– 326 KB

The SCE frequency was studied in cultures of peripheral lymphocytes from three subjects before and after vaccination against measles. The immunological vaccination reactions were monitored by antibody titration and by measurement of DNA synthesis in peripheral lymphocytes. In two of the subjects, on

Sister chromatid exchanges in human peri
Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals
โœ P. Hantson; C. Verellen-Dumoulin; J. M. Libouton; A. Leonard; E. D. Leonard; P. ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 263 KB

## Objective: To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals. ## Methods: Determination of the mean sister chromatid exchange (sce) frequency and the population of high-frequency cells (hfc, cells with a high sce frequency) in the peripheral blood lymphocy