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Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals

✍ Scribed by P. Hantson; C. Verellen-Dumoulin; J. M. Libouton; A. Leonard; E. D. Leonard; P. Mahieu

Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
263 KB
Volume
68
Category
Article
ISSN
0340-0131

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✦ Synopsis

Objective:

To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals.

Methods:

Determination of the mean sister chromatid exchange (sce) frequency and the population of high-frequency cells (hfc, cells with a high sce frequency) in the peripheral blood lymphocytes in four patients who ingested 150 mg kaso2, 1 g, 10 g and 20 g as2o3 respectively.

Results:

Doses of 10 g and 20 g significantly increased the hfc frequency and produced a shift in the distribution of the cells in accordance with the number of sces. the mean frequency of sces/cell was affected only after the highest dose (20 g).

Conclusion:

These results strongly suggest that cytogenetic methods are inappropriate for biomonitoring people occupationally exposed to arsenicals.

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