The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giemsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10-6M and 2 x 10-6M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitiv
Elevated sister chromatid exchange (SCE) rate in patients with sun-induced skin tumors
β Scribed by E. G. Jung; P. Luchsinger; E. Bohnert
- Publisher
- Springer-Verlag
- Year
- 1981
- Tongue
- English
- Weight
- 354 KB
- Volume
- 272
- Category
- Article
- ISSN
- 0340-3696
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An elevated sister chromatid exchange (SCE) rate was found in the lymphocytes of six patients treated with arsenic. All had stigmata of arsenic use as well as biopsy-proven skin cancers. The arsenic exposed patients had a mean of 14.00 SCE/mitosis while 44 normal controls had a mean of 5.8 SCE/ mito
The frequency of SCE was investigated in peripheral lymphocytes of one patient with XP. Although lymphocytes did not show high levels of spontaneous chromosome damage, 10-s M Mitomycin C greatly increased the fi'equency of SCE, The results are interpreted as an expression of mutagen induced chromoso
The effect of benzpyrene on sister chromatid exchange was determined in PHA-stimulated lymphocytes of 18 patients with lung cancer and 11 controls without cancer or bronchopulmonary diseases. Patients and controls did not differ either with respect to the spontaneous rate of sister chromatid exchang