Investigation of the sister chromatid exchange (SCE) frequency in one patient with xeroderma pigmentosum

✍ Scribed by M. Went; Á. Szőrenyi; A. Polay; N. Simon

• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 178 KB
• Volume: 271
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00406685

✦ Synopsis

The frequency of SCE was investigated in peripheral lymphocytes of one patient with XP. Although lymphocytes did not show high levels of spontaneous chromosome damage, 10-s M Mitomycin C greatly increased the fi'equency of SCE, The results are interpreted as an expression of mutagen induced chromosomal instability due to impaired DNA repair, which is a significant anomaly of the disease.