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Effect of incubation temperature on the frequency of sister chromatid exchanges in Bloom's syndrome lymphocytes

✍ Scribed by J. West; M. J. Lyttleton; F. Giannelli

Publisher
Springer
Year
1981
Tongue
English
Weight
371 KB
Volume
59
Category
Article
ISSN
0340-6717

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Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r

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Sister chromatid exchange (SCE) has been studied in the fibroblasts of five Bloom's syndrome patients, one heterozygote, and two normal individuals. The high frequency of SCE already known in the lymphocytes of Bloom's syndrome was also found in the fibroblasts of all five patients. However, populat