18 F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [ 18 F]-fluoromisonidazole was prepared from 1,3-dibromo-2propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis
Application of microwave heating to the synthesis of [18F]fluoromisonidazole
β Scribed by Timothy J. McCarthy; Carmen S. Dence; Michael J. Welch
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 384 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0969-8043
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A rapid, one-pot synthesis of [isF]fluoromisonidazole (1H-l-(3-[isF]fluoro-2hydroxypropyl)-2-nitroimidazole) (1) starting from ['sF]fluoride and (2R)-(-)-glycidyl tosylate (2) is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled compound are ca.
## Abstract The radiosynthesis of a new [^18^F]fluoroalkylating agent, [^18^F]fluoroacetaldehyde, is described. It was produced using the Kornblum method by oxidation with dimethyl sulphoxide of 2β[^18^F]fluoroethyl __p__βtoluenesulphonate ([^18^F]FETos). In these conditions the oxidation proceeds
A route was devised to synthesize no-carrier-added or carrier-added C\*uFlp-fluorophenylhydratine from aqueous C'OFlfluoride. Key reaction in this three-step sequence is the reduction o f C1nFlp-fluorobenzenediazonium chloride with sodium cyanoborohydride. The utility of this method is demonstrated